10 Myths About GLP-1 Medications

In the realm of diabetes management and weight loss, GLP-1 medications have emerged as a significant innovation, offering effective solutions for improving metabolic health and quality of life. However, alongside their benefits, misconceptions and myths about GLP-1 receptor agonists run rampant from uneducated sources. From fears of severe side effects to misunderstandings about their mechanisms, separating fact from fiction is crucial for making informed decisions about these therapies. The best way to combat the negative perception of GLP-1 medications is by educating yourself so that when these concerns arise, you are equipped to educate.

Let's Debunk!

Myth 1: GLP-1 medications are only for people with type 2 diabetes.

Truth: GLP-1 receptor agonists were initially developed for type 2 diabetes management, but they are now also approved for use in people with obesity. According to the American Diabetes Association (ADA), GLP-1 receptor agonists have shown benefits in weight management and cardiovascular risk reduction beyond their glucose-lowering effects in people with type 2 diabetes—medications specifically FDA-approved for weight loss - Wegovy (semiglutide), & Zepound (Tirzepatide).

Explanation: GLP-1 receptor agonists were initially developed and widely used for type 2 diabetes management due to their ability to improve glycemic control by stimulating insulin secretion and inhibiting glucagon release. However, they have since been approved for use in people with obesity due to their additional benefits in weight management and cardiovascular risk reduction.

Source: American Diabetes Association. (2021). Standards of Medical Care in Diabetes—2021. Diabetes Care, 44(Supplement 1), S111-S124. doi:10.2337/dc21-S009

Myth 2: GLP-1 medications are insulin.

Truth: GLP-1 receptor agonists are not insulin. They work by mimicking the action of glucagon-like peptide-1 (GLP-1), a hormone that helps regulate blood sugar levels. Unlike insulin, GLP-1 medications stimulate insulin secretion in a glucose-dependent manner and suppress glucagon secretion, which helps lower blood sugar levels.

Explanation: GLP-1 receptor agonists are often mistaken for insulin because they are injectable medications used in diabetes management. However, they work differently from insulin. GLP-1 medications mimic the action of GLP-1, a hormone that helps regulate glucose metabolism by stimulating insulin secretion in response to meals, suppressing glucagon release, and slowing gastric emptying.

Source: Drucker, D. J. (2003). Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology, 124(6), 1717-1730. doi:10.1016/S0016-5085(03)00261-9

Myth 3: GLP-1 medications always cause nausea.

Truth: Nausea is a common side effect of GLP-1 medications, especially when starting treatment or increasing the dose. However, not everyone experiences nausea, and it often improves over time as the body adjusts to the medication. Choosing the right GLP-1 receptor agonist and starting with a lower dose can help minimize this side effect.

Source: Meier, J. J., & Nauck, M. A. (2016). Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes & Metabolism Journal, 40(6), 419-426. doi:10.4093/dmj.2016.40.6.419

Myth 4: GLP-1 usage for weight loss is cheating.

Truth: GLP-1 receptor agonists are approved medications for managing weight in addition to type 2 diabetes. They work by decreasing appetite, promoting a feeling of fullness, and helping to regulate blood sugar levels. Using GLP-1 medications as prescribed by healthcare providers is not cheating but rather a medically supported treatment option for weight management.

Explanation: This myth may stem from a misconception that using medications for weight loss is somehow unfair compared to traditional methods like diet and exercise. However, GLP-1 medications are approved treatments for weight management in individuals with the disease obesity or overweight. They are prescribed when lifestyle modifications alone are insufficient in achieving weight loss goals or improving metabolic outcomes.

Source: Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., ... & Tate, D. F. (2015). A randomized, controlled trial of 3.0 mg of liraglutide in weight management. New England Journal of Medicine, 373(1), 11-22. doi:10.1056/NEJMoa1411892

Myth 5: You can eat whatever you want and not workout on a GLP-1.

Truth: While GLP-1 medications can help regulate blood sugar levels and may aid in weight management, they are most effective when used in conjunction with a healthy diet and regular physical activity. Lifestyle factors such as diet and exercise play a crucial role in overall health and weight management, even when taking GLP-1 receptor agonists.

Source: American Diabetes Association. (2021). Standards of Medical Care in Diabetes—2021. Diabetes Care, 44(Supplement 1), S111-S124. doi:10.2337/dc21-S009

Myth 6: GLP-1s cause muscle loss.

Truth: GLP-1 receptor agonists are not associated with muscle loss. These medications primarily target glucose metabolism and weight management through effects on insulin and appetite regulation. They do not have direct effects on muscle tissue and are not known to cause muscle loss.

Explanation: Concerns about muscle loss may arise from a misunderstanding of how GLP-1 medications affect metabolism. Muscle loss is a concern with ANY massive weight loss, not just GLP-1-assisted weight loss. These medications primarily target glucose metabolism and weight management through effects on insulin secretion and appetite regulation. They do not directly impact muscle tissue and are not associated with muscle loss. Improvements in glycemic control and weight management with GLP-1 receptor agonists may support overall metabolic health and muscle maintenance when used alongside appropriate diet and exercise. It is important when on a weight loss journey to prioritize strength training and protein, to ensure you are not losing lean mass.

Source: Baggio, L. L., & Drucker, D. J. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology, 132(6), 2131-2157. doi:10.1053/j.gastro.2007.03.054

Myth 7: GLP-1s cause hair loss.

Truth: There is no credible evidence linking GLP-1 receptor agonists to hair loss. Hair loss can occur due to various factors, including genetics, hormonal changes, stress, malnutrition, and certain medical conditions, but GLP-1 medications are not known to be a cause. Malnutrition is the main source of hair loss when losing a massive amount of weight rapidly. It is important to implement a vitamin regimen that fills the nutritional gaps that you may have from eating less during your active weight loss phase.

(Jasmine's vitamin regimen - http://JasmineMartin21.thrive123.com)

Explanation: Many of the side effects attributed to GLP-1 medications, such as nausea, gastrointestinal discomfort, hair loss, or rapid weight loss, are commonly associated with any effective weight management program. When people experience significant weight loss, whether through lifestyle changes or medication, it can affect gastrointestinal function and nutrient absorption. These side effects are typically manageable and often diminish over time as the body adapts.

Source: Meier, J. J., & Nauck, M. A. (2016). Glucagon-like peptide 1 (GLP-1) in biology and pathology. Diabetes & Metabolism Journal, 40(6), 419-426. doi:10.4093/dmj.2016.40.6.419

Myth 8: GLP-1s cause stomach paralysis***

Truth: The evidence does not suggest that GLP-1 receptor agonists, alone, cause stomach paralysis. These medications work by enhancing the body's natural production of GLP-1 and slowing gastric emptying, which helps regulate insulin secretion and glucose metabolism. However, there have been a small percentage of users do experience gastroparesis and they are usually patients who have suffered from this issue in the past. However, once the medication is stopped, the issue typically reverses itself.

Explanation: Studies show that those who smoke, have diabetes, take beta blockers, and other medications are more likely to develop gastroparesis symptoms. However, only 4 cases (as of March 2024) had been linked to the use of Semiglutide.

Source: Drucker, D. J. (2003). Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology, 124(6), 1717-1730. doi:10.1016/S0016-5085(03)00261-9

Myth 9: GLP-1s are a new class of drugs.

Truth: GLP-1s have been FDA-approved for treating type 2 diabetes for over 15 years.

Explanation: GLP-1s were more recently discovered for off-label use for weight loss management and FDA-approved for weight loss. Many drugs are discovered to have successful benefits that are off-label from their original intention and a GLP-1 happens to be one of those drugs.

Myth 10: GLP-1 medications can cause pancreatic cancer.

Truth: There is no credible evidence linking GLP-1 medications to an increased risk of pancreatic cancer. Studies have shown conflicting results, but large-scale reviews and meta-analyses have generally not found a significant association between GLP-1 receptor agonists and pancreatic cancer.

Explanation: Concerns about pancreatic cancer arose from early observational studies that suggested a potential link between GLP-1 receptor agonists and an increased risk of pancreatic disease. Subsequent large-scale reviews and meta-analyses, however, have not found consistent evidence supporting this association. The FDA and EMA have extensively reviewed the safety data of GLP-1 medications and concluded that there is no increased risk of pancreatic cancer with their use.

Source: Egan, A. G., Blind, E., Dunder, K., de Graeff, P. A., Hummer, B. T., Bourcier, T., ... & MacDonald, K. (2014). Pancreatic safety of incretin-based drugs—FDA and EMA assessment. New England Journal of Medicine, 370(9), 794-797. doi:10.1056/NEJMp1314078

By dispelling these myths surrounding GLP-1 medications, we've highlighted their scientifically supported benefits in managing diabetes, aiding weight loss, and improving overall health. Armed with accurate information, you can now make informed decisions about incorporating GLP-1 therapies into your healthcare regimen. Remember, consulting with healthcare professionals is key to personalized treatment plans that suit your unique needs and goals. Embrace the facts, empower yourself, and journey towards better health with confidence and clarity.

Also, I cannot miss this opportunity to suggest you check out our Facts OVER Feelings merch. When you purchase from GLP1-life.com you are supporting further education and content creation. Thank you!

xoxo,

Jasmine